The Role of Mastication in Improving TGF- β Levels on the Inhibition of Streptococcus sanguinis and Streptococcus mutans in Gingivitis

Sitanaya, Rini and Lesmana, Hans and Sunariani, Jenny and JM, Harjanto and Achmad, Harun and Irayani, Surya and Abdullah, Nurwiyana (2022) The Role of Mastication in Improving TGF- β Levels on the Inhibition of Streptococcus sanguinis and Streptococcus mutans in Gingivitis. Journal of International Dental and Medical Research, 15 (1). ISSN ISSN 1309-100X

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Abstract

Dental plaque in gingivitis containing 56% gram-positive bacteria and 44% gram-negative bacteria. The most dominant gram-positive species are Streptococcus sanguinis and Streptococcus mutans. Moreover, Transforming Growth Factor Beta (TGF- ) is a peptide for regulating proliferation, differentiation, and mortality of various cells, that can be increasingly secreted by parasympathetic stimulation through a mastication. To evaluate the effect of mastication intervention to TGF-β levels, the number of Streptococcus sanguinis and Streptococcus mutans, and the correlation between TGF-β levels and the number of Streptococcus sanguinis and Streptococcus mutans. 42 men of 17-22 years old were divided into 3 groups: group of healthy with mastication (G1); group of gingivitis with mastication (G2); and group of gingivitis without mastication (G3). The subjects who got a treatment had to chew normal gums (equal size, without sweetener and tastener) and did the mastication for a minute as much as 32 times, every morning after waking up in a week. After a week, the subject’s saliva sample was collected and the TGF-β levels, the number of S. sanguinis and S. mutans colony were counted with ELISA and RT PCR. The data was statistically analyzed with Mann Whitney U-test and Spearman’s correlation test. There was a significant difference of TGF-β levels on all groups (p<0.05) and the number of S. sanguinis between group G1:G3 and group G2:G3 (p<0.05). The numbers of S. mutans did not show any difference among all groups (p>0.05). Besides that, there was a correlation between the increased of TGF-β levels to the decreased number of S. sanguinis (p<0.05).

Item Type:	Article
Subjects:	R Medicine > RK Dentistry
Divisions:	Poltekkes Kemenkes Makassar > Jurusan Kesehatan Gigi
Depositing User:	Elsi Elsi Premiwati
Date Deposited:	31 Dec 2024 06:35
Last Modified:	31 Dec 2024 06:35
URI:	http://repositorynew.poltekkes-mks.ac.id/id/eprint/120

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